Low blood cell counts: OPZELURA may cause low platelet counts (thrombocytopenia), low red blood cell counts (anemia), and low white blood cell counts (neutropenia). Blood clots in the vein of the legs (deep vein thrombosis, DVT) and lungs (pulmonary embolism, PE) have happened more often in people who are 50 years of age and older and with at least 1 heart disease (cardiovascular) risk factor taking a medicine in the class of medicines called JAK inhibitors by mouth. Increased risk of major cardiovascular events: Increased risk of major cardiovascular events such as heart attack, stroke, or death have happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and taking a medicine in the class of medicines called JAK inhibitors by mouth, especially in current or past smokers.īlood clots: Blood clots in the veins of your legs (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE) can happen in some people taking OPZELURA. Wear protective clothing when you are in the sun and use a broad-spectrum sunscreen. Limit the amount of time you spend in the sunlight.
VAGINAL ITCH CREAM WALMART SKIN
Your healthcare provider will regularly check your skin during your treatment with OPZELURA. Some people have had skin cancers while using OPZELURA. People taking JAK inhibitors by mouth have a higher risk of certain cancers including lymphoma and lung cancer, especially if they are a current or past smoker. Lymphoma and other cancers have happened in people taking a medicine in the class of medicines called JAK inhibitors by mouth. Increased risk of death due to any reason (all causes): Increased risk of death has happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and are taking a medicine in the class of medicines called JAK inhibitors by mouth.Ĭancer and immune system problems: OPZELURA may increase your risk of certain cancers by changing the way your immune system works. You may be at a higher risk of developing shingles (herpes zoster) while using OPZELURA. You should not start using OPZELURA if you have any kind of infection unless your healthcare provider tells you it is okay.
OPZELURA should not be used in people with an active, serious infection, including localized infections. Your healthcare provider should watch you closely for signs and symptoms of TB during treatment with OPZELURA. Some people have had serious infections of their lungs while taking OPZELURA. Some people have been hospitalized or died from these infections. Some people have had serious infections while taking JAK inhibitors by mouth, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. JAK inhibitors can lower the ability of your immune system to fight infections.
JAK inhibitors are medicines that affect your immune system. Ruxolitinib belongs to a class of medicines called Janus kinase (JAK) inhibitors. Serious Infections: OPZELURA contains ruxolitinib. OPZELURA may cause serious side effects, including: Do not use OPZELURA in your eyes, mouth, or vagina.
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